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1bhg

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[[Image:1bhg.gif|left|200px]]
[[Image:1bhg.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bhg |SIZE=350|CAPTION= <scene name='initialview01'>1bhg</scene>, resolution 2.53&Aring;
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The line below this paragraph, containing "STRUCTURE_1bhg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucuronidase Beta-glucuronidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.31 3.2.1.31] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HUMAN PLACENTAL GUS GENE CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1bhg| PDB=1bhg | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bhg OCA], [http://www.ebi.ac.uk/pdbsum/1bhg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bhg RCSB]</span>
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}}
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'''HUMAN BETA-GLUCURONIDASE AT 2.6 A RESOLUTION'''
'''HUMAN BETA-GLUCURONIDASE AT 2.6 A RESOLUTION'''
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[[Category: Drendel, W B.]]
[[Category: Drendel, W B.]]
[[Category: Jain, S.]]
[[Category: Jain, S.]]
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[[Category: acid hydrolase]]
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[[Category: Acid hydrolase]]
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[[Category: glycosidase]]
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[[Category: Glycosidase]]
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[[Category: lysosomal enzyme]]
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[[Category: Lysosomal enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:31:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:01:00 2008''
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Revision as of 08:31, 2 May 2008

Image:1bhg.gif

Template:STRUCTURE 1bhg

HUMAN BETA-GLUCURONIDASE AT 2.6 A RESOLUTION


Overview

The X-ray structure of the homotetrameric lysosomal acid hydrolase, human beta-glucuronidase (332,000 Mr), has been determined at 2.6 A resolution. The tetramer has approximate dihedral symmetry and each promoter consists of three structural domains with topologies similar to a jelly roll barrel, an immunoglobulin constant domain and a TIM barrel respectively. Residues 179-204 form a beta-hairpin motif similar to the putative lysosomal targeting motif of cathepsin D, supporting the view that lysosomal targeting has a structural basis. The active site of the enzyme is formed from a large cleft at the interface of two monomers. Residues Glu 451 and Glu 540 are proposed to be important for catalysis. The structure establishes a framework for understanding mutations that lead to the human genetic disease mucopolysaccharidosis VII, and for using the enzyme in anti-cancer therapy.

About this Structure

1BHG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs., Jain S, Drendel WB, Chen ZW, Mathews FS, Sly WS, Grubb JH, Nat Struct Biol. 1996 Apr;3(4):375-81. PMID:8599764 Page seeded by OCA on Fri May 2 11:31:05 2008

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