6xwx
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of the Tof1-Csm3 complex== | ==Crystal structure of the Tof1-Csm3 complex== | ||
| - | <StructureSection load='6xwx' size='340' side='right'caption='[[6xwx]]' scene=''> | + | <StructureSection load='6xwx' size='340' side='right'caption='[[6xwx]], [[Resolution|resolution]] 3.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XWX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XWX FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xwx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XWX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XWX FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xwx OCA], [http://pdbe.org/6xwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xwx RCSB], [http://www.ebi.ac.uk/pdbsum/6xwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xwx ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0029130 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD]), CTHT_0011090 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xwx OCA], [http://pdbe.org/6xwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xwx RCSB], [http://www.ebi.ac.uk/pdbsum/6xwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xwx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/G0S0S7_CHATD G0S0S7_CHATD]] Plays an important role in the control of DNA replication and the maintenance of replication fork stability.[RuleBase:RU366049] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Tof1-Csm3 fork protection complex has a central role in the replisome-it promotes the progression of DNA replication forks and protects them when they stall, while also enabling cohesion establishment and checkpoint responses. Here, I present the crystal structure of the Tof1-Csm3 complex from Chaetomium thermophilum at 3.1 A resolution. The structure reveals that both proteins together form an extended alpha helical repeat structure, which suggests a mechanical or scaffolding role for the complex. Expanding on this idea, I characterize a DNA interacting region and a cancer-associated Mrc1 binding site. This study provides the molecular basis for understanding the functions of the Tof1-Csm3 complex, its human orthologue the Timeless-Tipin complex and additionally the Drosophila circadian rhythm protein Timeless. | ||
| + | |||
| + | Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.,Grabarczyk DB Nucleic Acids Res. 2020 May 29. pii: 5848492. doi: 10.1093/nar/gkaa456. PMID:32469068<ref>PMID:32469068</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6xwx" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Chatd]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Grabarczyk | + | [[Category: Grabarczyk, D B]] |
| + | [[Category: Armadillo repeat]] | ||
| + | [[Category: Cohesion establishment]] | ||
| + | [[Category: Fork protection complex]] | ||
| + | [[Category: Replication]] | ||
| + | [[Category: Replisome]] | ||
| + | [[Category: S phase checkpoint]] | ||
Revision as of 06:51, 10 June 2020
Crystal structure of the Tof1-Csm3 complex
| |||||||||||
