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5j6d

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==Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors==
==Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors==
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<StructureSection load='5j6d' size='340' side='right' caption='[[5j6d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5j6d' size='340' side='right'caption='[[5j6d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j6d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J6D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j6d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J6D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J6D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6H5:4-[(N-{[2-(3-METHOXYPHENOXY)-6-(PIPERIDIN-1-YL)PHENYL]METHYL}CARBAMIMIDOYL)CARBAMOYL]-L-PHENYLALANINE'>6H5</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6H5:4-[(N-{[2-(3-METHOXYPHENOXY)-6-(PIPERIDIN-1-YL)PHENYL]METHYL}CARBAMIMIDOYL)CARBAMOYL]-L-PHENYLALANINE'>6H5</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPH1, TPH, TPRH, TRPH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j6d OCA], [http://pdbe.org/5j6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j6d RCSB], [http://www.ebi.ac.uk/pdbsum/5j6d PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j6d OCA], [http://pdbe.org/5j6d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j6d RCSB], [http://www.ebi.ac.uk/pdbsum/5j6d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j6d ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</div>
</div>
<div class="pdbe-citations 5j6d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5j6d" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Tryptophan 5-monooxygenase]]
[[Category: Tryptophan 5-monooxygenase]]
[[Category: Goldberg, D R]]
[[Category: Goldberg, D R]]

Revision as of 07:31, 10 June 2020

Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors

PDB ID 5j6d

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