5j7e
From Proteopedia
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==hEAG PAS domain== | ==hEAG PAS domain== | ||
| - | <StructureSection load='5j7e' size='340' side='right' caption='[[5j7e]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='5j7e' size='340' side='right'caption='[[5j7e]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[5j7e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J7E FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNH1, EAG, EAG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7e OCA], [http://pdbe.org/5j7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j7e RCSB], [http://www.ebi.ac.uk/pdbsum/5j7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN]] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref> | [[http://www.uniprot.org/uniprot/KCNH1_HUMAN KCNH1_HUMAN]] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).[UniProtKB:Q60603]<ref>PMID:22732247</ref> <ref>PMID:23881642</ref> <ref>PMID:9738473</ref> | ||
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| + | ==See Also== | ||
| + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Juan, S]] | [[Category: Juan, S]] | ||
[[Category: Xiaohong, Q]] | [[Category: Xiaohong, Q]] | ||
Revision as of 07:32, 10 June 2020
hEAG PAS domain
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