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Autophagy-related protein
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Yeast Atg7 C terminal (green) complex with Atg8 (magenta) and Zn+2 ion (grey) (PDB code [[3vh3]])' scene='70/708076/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Yeast Atg7 C terminal (green) complex with Atg8 (magenta) and Zn+2 ion (grey) (PDB code [[3vh3]])' scene='70/708076/Cv/1'> | ||
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'''Autophagy-related proteins''' (Atg) function in autophagosome formation from the pre-autophagosomal structure (PAS). The phagosomes perform protein degradation under starvation. Autophagy is the process of forming a vacuole around proteins or nucleic acids destined to be broken down. This vacuole is a double membrane enclosure called phagophore. Atgs have non-autophagic functions as well as they are involved in cell survival and apoptosis.<ref>PMID:26382870</ref> So far 34 Atgs have been identified in yeast. <br /> | '''Autophagy-related proteins''' (Atg) function in autophagosome formation from the pre-autophagosomal structure (PAS). The phagosomes perform protein degradation under starvation. Autophagy is the process of forming a vacuole around proteins or nucleic acids destined to be broken down. This vacuole is a double membrane enclosure called phagophore. Atgs have non-autophagic functions as well as they are involved in cell survival and apoptosis.<ref>PMID:26382870</ref> So far 34 Atgs have been identified in yeast. <br /> | ||
*'''Atg1, 6, 14''' are involved in the formation of the phagophore. <br /> | *'''Atg1, 6, 14''' are involved in the formation of the phagophore. <br /> | ||
Revision as of 10:13, 14 June 2020
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References
- ↑ Shibutani ST, Saitoh T, Nowag H, Munz C, Yoshimori T. Autophagy and autophagy-related proteins in the immune system. Nat Immunol. 2015 Sep 18;16(10):1014-24. doi: 10.1038/ni.3273. PMID:26382870 doi:http://dx.doi.org/10.1038/ni.3273
- ↑ Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y, Inagaki F. Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol Cell. 2011 Nov 4;44(3):462-75. PMID:22055191 doi:10.1016/j.molcel.2011.08.035
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