1bi9
From Proteopedia
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[[Image:1bi9.gif|left|200px]] | [[Image:1bi9.gif|left|200px]] | ||
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'''RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND''' | '''RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND''' | ||
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[[Category: Lamb, A L.]] | [[Category: Lamb, A L.]] | ||
[[Category: Newcomer, M E.]] | [[Category: Newcomer, M E.]] | ||
| - | [[Category: | + | [[Category: Aldehyde dehydrogenase]] |
| - | [[Category: | + | [[Category: Retinoid]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:32:48 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:32, 2 May 2008
RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND
Overview
Retinoic acid, a hormonally active form of vitamin A, is produced in vivo in a two step process: retinol is oxidized to retinal and retinal is oxidized to retinoic acid. Retinal dehydrogenase type II (RalDH2) catalyzes this last step in the production of retinoic acid in the early embryo, possibly producing this putative morphogen to initiate pattern formation. The enzyme is also found in the adult animal, where it is expressed in the testis, lung, and brain among other tissues. The crystal structure of retinal dehydrogenase type II cocrystallized with nicotinamide adenine dinucleotide (NAD) has been determined at 2.7 A resolution. The structure was solved by molecular replacement using the crystal structure of a mitochondrial aldehyde dehydrogenase (ALDH2) as a model. Unlike what has been described for the structures of two aldehyde dehydrogenases involved in the metabolism of acetaldehyde, the substrate access channel is not a preformed cavity into which acetaldehyde can readily diffuse. Retinal dehydrogenase appears to utilize a disordered loop in the substrate access channel to discriminate between retinaldehyde and short-chain aldehydes.
About this Structure
1BI9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity., Lamb AL, Newcomer ME, Biochemistry. 1999 May 11;38(19):6003-11. PMID:10320326 Page seeded by OCA on Fri May 2 11:32:48 2008
