1bic

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[[Image:1bic.gif|left|200px]]
[[Image:1bic.gif|left|200px]]
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{{Structure
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|PDB= 1bic |SIZE=350|CAPTION= <scene name='initialview01'>1bic</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1bic", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
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{{STRUCTURE_1bic| PDB=1bic | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bic OCA], [http://www.ebi.ac.uk/pdbsum/1bic PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bic RCSB]</span>
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'''CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-'''
'''CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-'''
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[[Category: Vidgren, J.]]
[[Category: Vidgren, J.]]
[[Category: Xue, Y.]]
[[Category: Xue, Y.]]
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[[Category: lyase(oxo-acid)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:33:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:01:32 2008''
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Revision as of 08:33, 2 May 2008

Image:1bic.gif

Template:STRUCTURE 1bic

CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3-


Overview

A complex of carbonic anhydrase (CA) with one of its substrates, bicarbonate, has been studied crystallographically. Human isoenzyme II was mutated at position 200 from threonine to histidine, which results in higher affinity for bicarbonate. The HCO3- ion binds in the active site to the zinc ion as a pseudo-bidentate ligand which gives the metal a coordination geometry between tetrahedral and trigonal bipyramide. The water/hydroxide normally bound with tetrahedral coordination to the zinc is probably replaced by the OH group of the bicarbonate ion. The importance of residues Thr-199 and Glu-106 in controlling the binding orientation of HCO3- is discussed as well as the catalytic mechanism. Both the complex as well as the uncomplexed mutant were studied at 1.9 A resolution.

About this Structure

1BIC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-., Xue Y, Vidgren J, Svensson LA, Liljas A, Jonsson BH, Lindskog S, Proteins. 1993 Jan;15(1):80-7. PMID:8451242 Page seeded by OCA on Fri May 2 11:33:02 2008

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