1b03

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SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE

Overview

The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in, complex with the Fv fragment of an anti-gp120 antibody reveals an, unexpected type VI beta-turn comprising residues RGPG at the center of a, beta-hairpin. The central glycine and proline of this turn are linked by a, cis peptide bond. The residues of the turn interact extensively with the, antibody Fv. 15N[1H] NOE measurements show that the backbone of the, peptide, including the central QRGPGR loop, is well ordered in the, complex. The solution structure is significantly different from the X-ray, structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These, differences could be due to a two-residue (QR) insertion preceding the, GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope, immobilized by the anti-gp120 antibody.

About this Structure

1B03 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide., Tugarinov V, Zvi A, Levy R, Anglister J, Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:10201400

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