Phospholipase A2 homolog
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The complex between PLA2 homolog and the inhibitor suramin shows the inhibitor interacting with both monomers. | + | The <scene name='84/845943/Cv/4'>complex between PLA2 homolog and the inhibitor suramin shows the inhibitor interacting with both monomers</scene>. The location of PLA2 active site conserved Asp49 which is substituted by Lys in PLA2 homologs thus rendering PLA2<ref>PMID:26457430</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 09:26, 17 June 2020
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3D structures of phospholipase A2 homolog
Updated on 17-June-2020
References
- ↑ Lomonte B, Angulo Y, Sasa M, Gutierrez JM. The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles. Protein Pept Lett. 2009;16(8):860-76. doi: 10.2174/092986609788923356. PMID:19689412 doi:http://dx.doi.org/10.2174/092986609788923356
- ↑ Salvador GH, Dreyer TR, Cavalcante WL, Matioli FF, Dos Santos JI, Velazquez-Campoy A, Gallacci M, Fontes MR. Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin. Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2066-78. doi:, 10.1107/S1399004715014443. Epub 2015 Sep 26. PMID:26457430 doi:http://dx.doi.org/10.1107/S1399004715014443
