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1bjf

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[[Image:1bjf.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1bjf", creates the "Structure Box" on the page.
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{{STRUCTURE_1bjf| PDB=1bjf | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bjf OCA], [http://www.ebi.ac.uk/pdbsum/1bjf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bjf RCSB]</span>
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'''CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS'''
'''CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS'''
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[[Category: Kumar, V D.]]
[[Category: Kumar, V D.]]
[[Category: Vijay-Kumar, S.]]
[[Category: Vijay-Kumar, S.]]
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[[Category: calcium-binding]]
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[[Category: Calcium-binding]]
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[[Category: myristoylation]]
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[[Category: Myristoylation]]
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[[Category: neuronal specific guanylate cyclase activator]]
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[[Category: Neuronal specific guanylate cyclase activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:35:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:02:16 2008''
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Revision as of 08:35, 2 May 2008

Image:1bjf.jpg

Template:STRUCTURE 1bjf

CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS


Overview

The crystal structure of calcium-bound unmyristoylated bovine neurocalcin from Escherichia coli has been determined at 2.4 A resolution. The three-dimensional structure reveals a highly compact structure consisting of: (i) two pairs of calcium-binding EF-hands (EF1-EF2 and EF3-EF4); (ii) a calcium ion bound at EF2, EF3 and EF4 sites; and (iii) an EF1-hand that is disabled from calcium-binding due to a Cys-Pro sequence in the Ca2+-binding loop. The crystal structure of neurocalcin resembles photoreceptor recoverin in overall topology, however its EF2- and EF4-hands differ. Recently, neurocalcin in the calcium-bound state has been shown to stimulate mammalian rod outer segment membrane guanylate cyclase. A possible site for cyclase activity based on the three-dimensional structure is discussed.

About this Structure

1BJF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of recombinant bovine neurocalcin., Vijay-Kumar S, Kumar VD, Nat Struct Biol. 1999 Jan;6(1):80-8. PMID:9886296 Page seeded by OCA on Fri May 2 11:35:42 2008

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