1bau
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1bau" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bau" /> '''NMR STRUCTURE OF THE DIMER INITIATION COMPL...)
Next diff →
Revision as of 11:47, 8 November 2007
|
NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE
Overview
Retroviral genomes must dimerize to be fully infectious. Dimerization is, directed by a unique RNA hairpin structure with a palindrome in its loop:, hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the, initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and, metastable, its interface being formed not only by standard basepairing, between palindromes, but also by a distinctive pattern of interstrand, stacking among bases at the stem-loop junctions. This creates mechanical, distortions that partially melt both stems, which may facilitate, spontaneous refolding of this RNA complex into linear form.
About this Structure
1BAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:9628479
Page seeded by OCA on Thu Nov 8 13:53:11 2007
