1bjt

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[[Image:1bjt.gif|left|200px]]
[[Image:1bjt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bjt |SIZE=350|CAPTION= <scene name='initialview01'>1bjt</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1bjt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1bjt| PDB=1bjt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bjt OCA], [http://www.ebi.ac.uk/pdbsum/1bjt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bjt RCSB]</span>
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}}
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'''TOPOISOMERASE II RESIDUES 409-1201'''
'''TOPOISOMERASE II RESIDUES 409-1201'''
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==Reference==
==Reference==
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands., Fass D, Bogden CE, Berger JM, Nat Struct Biol. 1999 Apr;6(4):322-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10201398 10201398]
Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands., Fass D, Bogden CE, Berger JM, Nat Struct Biol. 1999 Apr;6(4):322-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10201398 10201398]
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[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
 
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Bogden, C E.]]
[[Category: Bogden, C E.]]
[[Category: Fass, D.]]
[[Category: Fass, D.]]
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[[Category: dna topology]]
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[[Category: Dna topology]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: quaternary change]]
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[[Category: Quaternary change]]
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[[Category: topoisomerase]]
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[[Category: Topoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:36:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:02:26 2008''
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Revision as of 08:36, 2 May 2008

Image:1bjt.gif

Template:STRUCTURE 1bjt

TOPOISOMERASE II RESIDUES 409-1201


Overview

Type II DNA topoisomerases mediate the passage of one DNA duplex through a transient break in another, an event essential for chromosome segregation and cell viability. The active sites of the type II topoisomerase dimer associate covalently with the DNA break-points and must separate by at least the width of the second DNA duplex to accommodate transport. A new structure of the Saccharomyces cerevisiae topoisomerase II DNA-binding and cleavage core suggests that in addition to conformational changes in the DNA-opening platform, a dramatic reorganization of accessory domains may occur during catalysis. These conformational differences have implications for both the DNA-breaking and duplex-transport events in the topo II reaction mechanism, suggest a mechanism by which two distinct drug-resistance loci interact, and illustrate the scope of structural changes in the cycling of molecular machines.

About this Structure

1BJT is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands., Fass D, Bogden CE, Berger JM, Nat Struct Biol. 1999 Apr;6(4):322-6. PMID:10201398 Page seeded by OCA on Fri May 2 11:36:23 2008

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