1bjx

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[[Image:1bjx.gif|left|200px]]
[[Image:1bjx.gif|left|200px]]
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{{Structure
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|PDB= 1bjx |SIZE=350|CAPTION= <scene name='initialview01'>1bjx</scene>
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The line below this paragraph, containing "STRUCTURE_1bjx", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span>
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{{STRUCTURE_1bjx| PDB=1bjx | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bjx OCA], [http://www.ebi.ac.uk/pdbsum/1bjx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bjx RCSB]</span>
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'''HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 24 STRUCTURES'''
'''HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 24 STRUCTURES'''
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[[Category: Penka, E.]]
[[Category: Penka, E.]]
[[Category: Scheek, R M.]]
[[Category: Scheek, R M.]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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[[Category: endoplasmic reticulum]]
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[[Category: Endoplasmic reticulum]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: redox-active center]]
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[[Category: Redox-active center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:36:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:02:32 2008''
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Revision as of 08:36, 2 May 2008

Image:1bjx.gif

Template:STRUCTURE 1bjx

HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 24 STRUCTURES


Overview

Protein disulfide isomerase (PDI) is a multifunctional protein of the endoplasmic reticulum, which catalyzes the formation, breakage and rearrangement of disulfide bonds during protein folding. It consists of four domains designated a, b, b and a. Both a and a domains contains an active site with the sequence motif -Cys-Gly-His-Cys-involved directly in thiol-disulfide exchange reactions. As expected these domains have structures very similar to the ubiquitous redox protein thioredoxin. A low-resolution NMR structure of the b domain revealed that this domain adopts a fold similar to the PDI a domain and thioredoxin [Kemmink, J., Darby, N.J., Dijkstra, K., Nilges, M. and Creighton, T.E. (1997) Curr. Biol. 7, 239-245]. A refined ensemble of solution structures based on the input of 1865 structural restraints shows that the structure of PDI b is well defined throughout the complete protein except for about 10 residues at the C-terminus of the sequence. 15N relaxation data show that these residues are disordered and not part of this structural domain. Therefore the domain boundaries of PDI can now be fixed with reasonable precision. Structural comparison of the PDI b domain with thioredoxin and PDI a reveals several features important for thiol-disulfide exchange activity.

About this Structure

1BJX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure in solution of the b domain of protein disulfide isomerase., Kemmink J, Dijkstra K, Mariani M, Scheek RM, Penka E, Nilges M, Darby NJ, J Biomol NMR. 1999 Apr;13(4):357-68. PMID:10383197 Page seeded by OCA on Fri May 2 11:36:43 2008

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