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| - | <StructureSection load='1q7b' size='350' side='right' caption='Structure of beta-ketoacyl carrier protein reductase complex with NADP and Ca+2 ion (green) (PDB code [[1q7b]]).' scene='59/593279/Cv/1'>
| + | #REDIRECT [[Beta-hydroxyacyl-acyl_carrier_protein_dehydratase]] |
| - | __TOC__
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| - | == Function ==
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| - | '''Beta-ketoacyl carrier protein reductase''' (BKACPR) catalyzes the reaction of conversion of 3-hydroxyacyl-[acyl-carrier-protein] to 3-oxoacyl-[acyl-carrier-protein] while using NADPH as a reducing agent. BKACPR is part of the type II fatty acid biosynthesis pathway. '''Pimelyl carrier protein reductase''' (ACPR) is involved in the assembly pathway of the pimeloyl moiety of biotin.
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| - | == Relevance ==
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| - | BKACPR from ''Plasmodium falciparium'' inhibitors are tested as antimalarial drugs. Other BKACPR inhibitors are tested for combating toxoplasmosis and sleeping sickness.
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| - | == Structural highlights ==
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| - | The <scene name='59/593279/Cv/4'>active site</scene> interacting with co-factor NADPH contains the active site catalytic triad <scene name='59/593279/Cv/5'>S138, Y151, K155</scene> (in E. coli, PDB code [[1q7b]]).<ref>PMID:15016358</ref> Water molecules are shown as red spheres.
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| - | ==3D structures of beta-ketoacyl carrier protein reductase==
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| - | [[Beta-ketoacyl carrier protein reductase 3D structures]]
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| - | </StructureSection>
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| - | == References ==
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| - | <references/>
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| - | [[Category:Topic Page]]
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Current revision
- REDIRECT Beta-hydroxyacyl-acyl_carrier_protein_dehydratase
