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1bn0

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(New page: 200px<br /> <applet load="1bn0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bn0" /> '''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HI...)
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Revision as of 11:48, 8 November 2007

Image:1bn0.gif

1bn0

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SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES

Overview

An NMR-based structure is presented for a 20 mer hairpin model of the SL3, stem-loop from the HIV-1 packaging signal. The stem has an A-family, structure. However, the GGAG tetraloop appears to be flexible with the, second (G10) and fourth (G12) bases extruded from the normal stacking, arrangement. The A-base (A11) occupies a cavity large enough for it to, jump rapidly between stacking upon G9 (in the loop) and G13 (from the, base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12, are unoccupied in the free RNA structure. The loop should be easily, adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.

About this Structure

1BN0 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628

Page seeded by OCA on Thu Nov 8 13:54:10 2007

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