1blx

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[[Image:1blx.gif|left|200px]]
[[Image:1blx.gif|left|200px]]
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{{Structure
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|PDB= 1blx |SIZE=350|CAPTION= <scene name='initialview01'>1blx</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1blx", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CAB:Ca+Binding+Site'>CAB</scene>
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{{STRUCTURE_1blx| PDB=1blx | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1blx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1blx OCA], [http://www.ebi.ac.uk/pdbsum/1blx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1blx RCSB]</span>
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'''P19INK4D/CDK6 COMPLEX'''
'''P19INK4D/CDK6 COMPLEX'''
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[[Category: Wick, S.]]
[[Category: Wick, S.]]
[[Category: Xu, X.]]
[[Category: Xu, X.]]
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[[Category: alpha/beta]]
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[[Category: Alpha/beta]]
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[[Category: cell cycle control]]
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[[Category: Cell cycle control]]
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[[Category: complex (inhibitor protein/kinase)]]
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[[Category: Cyclin-dependent kinase]]
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[[Category: cyclin-dependent kinase]]
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[[Category: Inhibitor protein]]
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[[Category: inhibitor protein]]
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Revision as of 08:40, 2 May 2008

Image:1blx.gif

Template:STRUCTURE 1blx

P19INK4D/CDK6 COMPLEX


Overview

The crystal structure of the cyclin D-dependent kinase Cdk6 bound to the p19 INK4d protein has been determined at 1.9 A resolution. The results provide the first structural information for a cyclin D-dependent protein kinase and show how the INK4 family of CDK inhibitors bind. The structure indicates that the conformational changes induced by p19INK4d inhibit both productive binding of ATP and the cyclin-induced rearrangement of the kinase from an inactive to an active conformation. The structure also shows how binding of an INK4 inhibitor would prevent binding of p27Kip1, resulting in its redistribution to other CDKs. Identification of the critical residues involved in the interaction explains how mutations in Cdk4 and p16INK4a result in loss of kinase inhibition and cancer.

About this Structure

1BLX is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d., Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ, Serrano M, Brenner SL, Blundell TL, Laue ED, Nature. 1998 Sep 17;395(6699):244-50. PMID:9751051 Page seeded by OCA on Fri May 2 11:40:54 2008

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