1c0t
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(New page: 200px<br /> <applet load="1c0t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1c0t, resolution 2.7Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 11:49, 8 November 2007
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
Overview
We have determined the crystal structures of thiazoloisoindolinone, non-nucleoside inhibitors in complex with HIV-1 reverse transcriptase to, high-resolution limits of 2.7 A (BM +21.1326) and 2. 52 A (BM +50.0934)., We find that the binding modes of this series of inhibitors closely, resemble that of "two-ring" non-nucleoside reverse transcriptase, inhibitors. The structures allow rationalization of stereochemical, requirements, structure-activity data, and drug resistance data., Comparisons with our previous structures suggest modifications to the, inhibitors that might improve resilience to drug-resistant mutant forms of, reverse transcriptase. Comparison with earlier modeling studies reveals, that the predicted overlap of thiazoloisoindolinones with TIBO was largely, correct, while that with nevirapine was significantly different.
About this Structure
1C0T is a Protein complex structure of sequences from Human immunodeficiency virus 1 with BM1 as ligand. Active as RNA-directed DNA polymerase, with EC number 2.7.7.49 Full crystallographic information is available from OCA.
Reference
Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies., Ren J, Esnouf RM, Hopkins AL, Stuart DI, Stammers DK, J Med Chem. 1999 Sep 23;42(19):3845-51. PMID:10508433
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