1bma

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[[Image:1bma.gif|left|200px]]
[[Image:1bma.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bma |SIZE=350|CAPTION= <scene name='initialview01'>1bma</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1bma", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ISO:PARA-ISOPROPYLANILINE'>ISO</scene>, <scene name='pdbligand=MBH:1-BENZYL-1-METHYL-1-(2-ACETYL)HYDRAZINIUM+ION'>MBH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETYL+GROUP'>TFA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1bma| PDB=1bma | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bma OCA], [http://www.ebi.ac.uk/pdbsum/1bma PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bma RCSB]</span>
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}}
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'''BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE'''
'''BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE'''
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[[Category: Petsko, G A.]]
[[Category: Petsko, G A.]]
[[Category: Ringe, D.]]
[[Category: Ringe, D.]]
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[[Category: complex (serine protease/inhibitor)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:41:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:03:51 2008''
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Revision as of 08:41, 2 May 2008

Image:1bma.gif

Template:STRUCTURE 1bma

BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE


Overview

The crystal structure of an aminimide analog of a dipeptide inhibitor of porcine pancreatic elastase bound to its target serine protease has been solved. The peptidomimetic molecule binds in the same fashion as the class of dipeptides from which it was derived, making similar interactions with the subsites on the elastase surface. Because aminimides are readily synthesized from a wide variety of starting materials, they form the basis for a combinatorial chemistry approach to rational drug design.

About this Structure

1BMA is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Interaction of a peptidomimetic aminimide inhibitor with elastase., Peisach E, Casebier D, Gallion SL, Furth P, Petsko GA, Hogan JC Jr, Ringe D, Science. 1995 Jul 7;269(5220):66-9. PMID:7604279 Page seeded by OCA on Fri May 2 11:41:41 2008

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