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1bmp

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[[Image:1bmp.gif|left|200px]]
[[Image:1bmp.gif|left|200px]]
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{{Structure
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|PDB= 1bmp |SIZE=350|CAPTION= <scene name='initialview01'>1bmp</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1bmp", creates the "Structure Box" on the page.
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|GENE= HOP-1 CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1bmp| PDB=1bmp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bmp OCA], [http://www.ebi.ac.uk/pdbsum/1bmp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bmp RCSB]</span>
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'''BONE MORPHOGENETIC PROTEIN-7'''
'''BONE MORPHOGENETIC PROTEIN-7'''
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[[Category: Griffith, D L.]]
[[Category: Griffith, D L.]]
[[Category: Scott, D L.]]
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[[Category: bone]]
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[[Category: Bone]]
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[[Category: cartilage]]
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[[Category: Cartilage]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: morphogen]]
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[[Category: Morphogen]]
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[[Category: transforming growth factor]]
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[[Category: Transforming growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:42:24 2008''
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Revision as of 08:42, 2 May 2008

Image:1bmp.gif

Template:STRUCTURE 1bmp

BONE MORPHOGENETIC PROTEIN-7


Overview

We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.

About this Structure

1BMP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily., Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD, Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83. PMID:8570652 Page seeded by OCA on Fri May 2 11:42:24 2008

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