1bn9
From Proteopedia
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[[Image:1bn9.gif|left|200px]] | [[Image:1bn9.gif|left|200px]] | ||
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'''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA''' | '''RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN9 OCA]. | |
==Reference== | ==Reference== | ||
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*., Castagne C, Terenzi H, Zakin MM, Delepierre M, Biochimie. 2000 Aug;82(8):739-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11018291 11018291] | Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*., Castagne C, Terenzi H, Zakin MM, Delepierre M, Biochimie. 2000 Aug;82(8):739-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11018291 11018291] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Castagne, C.]] | [[Category: Castagne, C.]] | ||
[[Category: Delepierre, M.]] | [[Category: Delepierre, M.]] | ||
[[Category: Terenzi, H.]] | [[Category: Terenzi, H.]] | ||
[[Category: Zakin, M M.]] | [[Category: Zakin, M M.]] | ||
| - | [[Category: | + | [[Category: Dna]] |
| - | [[Category: | + | [[Category: Orphan nuclear receptor]] |
| - | [[Category: | + | [[Category: Response element]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:43:35 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:43, 2 May 2008
RESPONSE ELEMENT OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB BETA
Overview
Rev-erb beta is an orphan receptor that binds as a homodimer or as a monomer to DNA. The solution structure of the non-palindromic 15 bp DNA duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for monomeric binding, was determined by 1H and 31P NMR, energy minimization with NMR-derived restraints for distances and NOE back-calculation methods. The refined final structures have the typical overall features of B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA binding domain of Rev-erb beta, showed large shifts of imino protons and 31P signals, suggesting major conformational changes.
About this Structure
Full crystallographic information is available from OCA.
Reference
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*., Castagne C, Terenzi H, Zakin MM, Delepierre M, Biochimie. 2000 Aug;82(8):739-48. PMID:11018291 Page seeded by OCA on Fri May 2 11:43:35 2008
