1bo1

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[[Image:1bo1.jpg|left|200px]]
[[Image:1bo1.jpg|left|200px]]
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{{Structure
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|PDB= 1bo1 |SIZE=350|CAPTION= <scene name='initialview01'>1bo1</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1bo1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol-4-phosphate_5-kinase 1-phosphatidylinositol-4-phosphate 5-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.68 2.7.1.68] </span>
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{{STRUCTURE_1bo1| PDB=1bo1 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bo1 OCA], [http://www.ebi.ac.uk/pdbsum/1bo1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bo1 RCSB]</span>
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'''PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA'''
'''PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA'''
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[[Category: Misra, S.]]
[[Category: Misra, S.]]
[[Category: Rao, V D.]]
[[Category: Rao, V D.]]
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[[Category: lipid signaling]]
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[[Category: Lipid signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:45:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:04:49 2008''
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Revision as of 08:45, 2 May 2008

Image:1bo1.jpg

Template:STRUCTURE 1bo1

PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE II BETA


Overview

Phosphoinositide kinases play central roles in signal transduction by phosphorylating the inositol ring at specific positions. The structure of one such enzyme, type IIbeta phosphatidylinositol phosphate kinase, reveals a protein kinase ATP-binding core and demonstrates that all phosphoinositide kinases belong to one superfamily. The enzyme is a disc-shaped homodimer with a 33 x 48 A basic flat face that suggests an electrostatic mechanism for plasma membrane targeting. Conserved basic residues form a putative phosphatidylinositol phosphate specificity site. The substrate-binding site is open on one side, consistent with dual specificity for phosphatidylinositol 3- and 5-phosphates. A modeled complex with membrane-bound substrate and ATP shows how a phosphoinositide kinase can phosphorylate its substrate in situ at the membrane interface.

About this Structure

1BO1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation., Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH, Cell. 1998 Sep 18;94(6):829-39. PMID:9753329 Page seeded by OCA on Fri May 2 11:45:11 2008

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