1boa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1boa.gif|left|200px]]
[[Image:1boa.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1boa |SIZE=350|CAPTION= <scene name='initialview01'>1boa</scene>, resolution 1.8&Aring;
+
The line below this paragraph, containing "STRUCTURE_1boa", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=BND:Fumagillin+480+Forms+A+Covalent+Bond+w.+HIS+231'>BND</scene> and <scene name='pdbsite=CO2:Dicobalt+Active+Site'>CO2</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=FUG:FUMAGILLIN'>FUG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1boa| PDB=1boa | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1boa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1boa OCA], [http://www.ebi.ac.uk/pdbsum/1boa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1boa RCSB]</span>
+
-
}}
+
'''HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN'''
'''HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN'''
Line 31: Line 28:
[[Category: Liu, S.]]
[[Category: Liu, S.]]
[[Category: Widom, J.]]
[[Category: Widom, J.]]
-
[[Category: angiogenesis inhibitor]]
+
[[Category: Angiogenesis inhibitor]]
-
[[Category: fumagillin]]
+
[[Category: Fumagillin]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: methionine aminopeptidase]]
+
[[Category: Methionine aminopeptidase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:45:43 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:04:57 2008''
+

Revision as of 08:45, 2 May 2008

Image:1boa.gif

Template:STRUCTURE 1boa

HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN


Overview

The fungal metabolite fumagillin suppresses the formation of new blood vessels, and a fumagillin analog is currently in clinical trials as an anticancer agent. The molecular target of fumagillin is methionine aminopeptidase-2 (MetAP-2). A 1.8 A resolution crystal structure of free and inhibited human MetAP-2 shows a covalent bond formed between a reactive epoxide of fumagillin and histidine-231 in the active site of MetAP-2. Extensive hydrophobic and water-mediated polar interactions with other parts of fumagillin provide additional affinity. Fumagillin-based drugs inhibit MetAP-2 but not MetAP-1, and the three-dimensional structure also indicates the likely determinants of this specificity. The structural basis for fumagillin's potency and specificity forms the starting point for structure-based drug design.

About this Structure

1BOA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human methionine aminopeptidase-2 complexed with fumagillin., Liu S, Widom J, Kemp CW, Crews CM, Clardy J, Science. 1998 Nov 13;282(5392):1324-7. PMID:9812898 Page seeded by OCA on Fri May 2 11:45:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1boa"
Personal tools