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1bob

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[[Image:1bob.jpg|left|200px]]
[[Image:1bob.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1bob |SIZE=350|CAPTION= <scene name='initialview01'>1bob</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1bob", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1bob| PDB=1bob | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bob OCA], [http://www.ebi.ac.uk/pdbsum/1bob PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bob RCSB]</span>
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}}
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'''HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A'''
'''HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A'''
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[[Category: Sternglanz, R.]]
[[Category: Sternglanz, R.]]
[[Category: Tafrov, S T.]]
[[Category: Tafrov, S T.]]
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[[Category: acetyl coenzyme a binding-protein]]
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[[Category: Acetyl coenzyme a binding-protein]]
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[[Category: histone acetyltransferase]]
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[[Category: Histone acetyltransferase]]
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[[Category: histone modification]]
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[[Category: Histone modification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:45:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:05:00 2008''
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Revision as of 08:45, 2 May 2008

Template:STRUCTURE 1bob

HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A


Overview

We have solved the crystal structure of the yeast histone acetyltransferase Hat1-acetyl coenzyme A (AcCoA) complex at 2.3 A resolution. Hat1 has an elongated, curved structure, and the AcCoA molecule is bound in a cleft on the concave surface of the protein, marking the active site of the enzyme. A channel of variable width and depth that runs across the protein is probably the binding site for the histone substrate. A model for histone H4 binding by Hat1 is discussed in terms of possible sources of specific lysine recognition by the enzyme. The structure of Hat1 provides a model for the structures of the catalytic domains of a protein superfamily that includes other histone acetyltransferases such as Gcn5 and CBP.

About this Structure

1BOB is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily., Dutnall RN, Tafrov ST, Sternglanz R, Ramakrishnan V, Cell. 1998 Aug 21;94(4):427-38. PMID:9727486 Page seeded by OCA on Fri May 2 11:45:45 2008

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