1d4s

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(New page: 200px<br /> <applet load="1d4s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d4s, resolution 2.5&Aring;" /> '''HIV-1 PROTEASE V82F/...)
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Revision as of 11:51, 8 November 2007

Image:1d4s.gif

1d4s, resolution 2.5Å

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HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX

About this Structure

1D4S is a Single protein structure of sequence from Human immunodeficiency virus 1 with TPV as ligand. Active as HIV-1 retropepsin, with EC number 3.4.23.16 Full crystallographic information is available from OCA.

Reference

Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors., Thaisrivongs S, Skulnick HI, Turner SR, Strohbach JW, Tommasi RA, Johnson PD, Aristoff PA, Judge TM, Gammill RB, Morris JK, Romines KR, Chrusciel RA, Hinshaw RR, Chong KT, Tarpley WG, Poppe SM, Slade DE, Lynn JC, Horng MM, Tomich PK, Seest EP, Dolak LA, Howe WJ, Howard GM, Watenpaugh KD, et al., J Med Chem. 1996 Oct 25;39(22):4349-53. PMID:8893827

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