1bqb

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[[Image:1bqb.jpg|left|200px]]
[[Image:1bqb.jpg|left|200px]]
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{{Structure
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|PDB= 1bqb |SIZE=350|CAPTION= <scene name='initialview01'>1bqb</scene>, resolution 1.72&Aring;
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The line below this paragraph, containing "STRUCTURE_1bqb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span>
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{{STRUCTURE_1bqb| PDB=1bqb | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqb OCA], [http://www.ebi.ac.uk/pdbsum/1bqb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bqb RCSB]</span>
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'''AUREOLYSIN, STAPHYLOCOCCUS AUREUS METALLOPROTEINASE'''
'''AUREOLYSIN, STAPHYLOCOCCUS AUREUS METALLOPROTEINASE'''
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[[Category: Potempa, J.]]
[[Category: Potempa, J.]]
[[Category: Travis, J.]]
[[Category: Travis, J.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: metalloproteinase]]
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[[Category: Metalloproteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:49:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:06:03 2008''
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Revision as of 08:49, 2 May 2008

Image:1bqb.jpg

Template:STRUCTURE 1bqb

AUREOLYSIN, STAPHYLOCOCCUS AUREUS METALLOPROTEINASE


Overview

BACKGROUND: Aureolysin is an extracellular zinc-dependent metalloproteinase from the pathogenic bacterium Staphylococcus aureus. This enzyme exhibits in vitro activity against several molecules of biological significance for the host, indicating that it is involved in the pathology of staphylococcal diseases. RESULTS: Here we report the amino-acid sequence and inhibitor-free X-ray crystal structure of aureolysin, a member of the thermolysin family of zinc-dependent metalloproteinases. This enzyme, which binds one zinc and three calcium ions, comprises a single chain of 301 amino acids that consists of a beta-strand-rich upper domain and an alpha-helix-rich lower domain. CONCLUSIONS: The overall structure of aureolysin is very similar to that of the other three members of this family whose structures are known - thermolysin (TLN) from Bacillus thermoproteolyticus, neutral protease (NP) from Bacillus cereus and elastase (PAE) from Pseudomonas aeruginosa. But an important difference has been encountered: in contrast to what has been observed in the other three members of this family (TLN, NP and PAE), inhibitor-free aureolysin displays a 'closed' active site cleft conformation. This new structure therefore raises questions about the universality of the hinge-bending motion model for the neutral metalloproteinases.

About this Structure

1BQB is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Amino-acid sequence and three-dimensional structure of the Staphylococcus aureus metalloproteinase at 1.72 A resolution., Banbula A, Potempa J, Travis J, Fernandez-Catalan C, Mann K, Huber R, Bode W, Medrano F, Structure. 1998 Sep 15;6(9):1185-93. PMID:9753696 Page seeded by OCA on Fri May 2 11:49:35 2008

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