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1bqh

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[[Image:1bqh.gif|left|200px]]
[[Image:1bqh.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1bqh", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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{{STRUCTURE_1bqh| PDB=1bqh | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqh OCA], [http://www.ebi.ac.uk/pdbsum/1bqh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bqh RCSB]</span>
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'''MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8'''
'''MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8'''
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[[Category: Reinherz, E L.]]
[[Category: Reinherz, E L.]]
[[Category: Wang, J H.]]
[[Category: Wang, J H.]]
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[[Category: antigen]]
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[[Category: Antigen]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: coreceptor]]
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[[Category: Coreceptor]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: immunology]]
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[[Category: Immunology]]
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[[Category: signal]]
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[[Category: Signal]]
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[[Category: t-cell]]
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[[Category: T-cell]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:49:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:06:07 2008''
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Revision as of 08:49, 2 May 2008

Image:1bqh.gif

Template:STRUCTURE 1bqh

MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8


Overview

The crystal structure of the two immunoglobulin variable-like domains of the murine CD8alphaalpha homodimer complexed to the class I MHC H-2Kb molecule at 2.8 A resolution shows that CD8alphaalpha binds to the protruding MHC alpha3 domain loop in an antibody-like manner. Comparison of mouse CD8alphaalpha/H-2Kb and human CD8alphaalpha/HLA-A2 complexes reveals shared as well as species-specific recognition features. In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without discernable conformational alteration of the peptide or MHC antigen-presenting platform.

About this Structure

1BQH is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb., Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, Spoerl R, Chang HC, Reinherz EL, Wang JH, Immunity. 1998 Oct;9(4):519-30. PMID:9806638 Page seeded by OCA on Fri May 2 11:49:54 2008

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