1bqr

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[[Image:1bqr.gif|left|200px]]
[[Image:1bqr.gif|left|200px]]
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{{Structure
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|PDB= 1bqr |SIZE=350|CAPTION= <scene name='initialview01'>1bqr</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1bqr", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=COP:Reduced+Cu+Coordination'>COP</scene>
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>
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{{STRUCTURE_1bqr| PDB=1bqr | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqr OCA], [http://www.ebi.ac.uk/pdbsum/1bqr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bqr RCSB]</span>
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'''REDUCED PSEUDOAZURIN'''
'''REDUCED PSEUDOAZURIN'''
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[[Category: Shimomura, T.]]
[[Category: Shimomura, T.]]
[[Category: Suzuki, S.]]
[[Category: Suzuki, S.]]
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[[Category: cuproprotein]]
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[[Category: Cuproprotein]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:50:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:06:20 2008''
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Revision as of 08:50, 2 May 2008

Image:1bqr.gif

Template:STRUCTURE 1bqr

REDUCED PSEUDOAZURIN


Overview

The crystal structures of oxidized and reduced pseudoazurins from a denitrifying bacterium, Achromobacter cycloclastes IAM1013, have been determined at 1.35- and 1.6-A resolutions, respectively. The copper site in the oxidized state exhibits a distorted tetrahedral structure like those of other pseudoazurins. However, not only a small change of the copper geometry, but concerted peptide bond flips are identified. The imidazole ring of remote His6 has a hydrogen bonding distance of 2.73 A between N-delta1(His6) and O-gamma1(Thr36) in the oxidized protein. When the protein is reduced at pH 6.0, the imidazole ring rotates by 30.3 degrees and moves 1.00 A away from the position of the oxidized state. A new hydrogen bond between N-epsilon2(His6) and O-epsilon1(Glu4) is formed with a distance of 3.03 A, while the hydrogen bond between N-delta1(His6)-O-gamma1(Thr36) is maintained with an interatomic distance of 2.81 A. A concomitant peptide bond flip of main chain between Ile34 and Thr36 occurs.

About this Structure

1BQR is a Single protein structure of sequence from Achromobacter cycloclastes. Full crystallographic information is available from OCA.

Reference

Crystal structure determinations of oxidized and reduced pseudoazurins from Achromobacter cycloclastes. Concerted movement of copper site in redox forms with the rearrangement of hydrogen bond at a remote histidine., Inoue T, Nishio N, Suzuki S, Kataoka K, Kohzuma T, Kai Y, J Biol Chem. 1999 Jun 18;274(25):17845-52. PMID:10364229 Page seeded by OCA on Fri May 2 11:50:38 2008

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