1brr

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[[Image:1brr.gif|left|200px]]
[[Image:1brr.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1brr", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ARC:3,7,11,15-TETRAMETHYL-HEXADECAN-1-OL'>ARC</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=SGA:O3-SULFONYLGALACTOSE'>SGA</scene>
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{{STRUCTURE_1brr| PDB=1brr | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1brr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1brr OCA], [http://www.ebi.ac.uk/pdbsum/1brr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1brr RCSB]</span>
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'''X-RAY STRUCTURE OF THE BACTERIORHODOPSIN TRIMER/LIPID COMPLEX'''
'''X-RAY STRUCTURE OF THE BACTERIORHODOPSIN TRIMER/LIPID COMPLEX'''
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[[Category: Oesterhelt, D.]]
[[Category: Oesterhelt, D.]]
[[Category: Siegert, R.]]
[[Category: Siegert, R.]]
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[[Category: haloarchaea]]
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[[Category: Haloarchaea]]
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[[Category: lipid]]
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[[Category: Lipid]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: photoreceptor]]
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[[Category: Photoreceptor]]
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[[Category: proton pump]]
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[[Category: Proton pump]]
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[[Category: retinal protein]]
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[[Category: Retinal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:52:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:06:53 2008''
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Revision as of 08:52, 2 May 2008

Image:1brr.gif

Template:STRUCTURE 1brr

X-RAY STRUCTURE OF THE BACTERIORHODOPSIN TRIMER/LIPID COMPLEX


Overview

Heterogenous nucleation on small molecule crystals causes a monoclinic crystal form of bacteriorhodopsin (BR) in which trimers of this membrane protein pack differently than in native purple membranes. Analysis of single crystals by nano-electrospray ionization-mass spectrometry demonstrated a preservation of the purple membrane lipid composition in these BR crystals. The 2.9-A x-ray structure shows a lipid-mediated stabilization of BR trimers where the glycolipid S-TGA-1 binds into the central compartment of BR trimers. The BR trimer/lipid complex provides an example of local membrane thinning as the lipid head-group boundary of the central lipid patch is shifted by 5 A toward the membrane center. Nonbiased electron density maps reveal structural differences to previously reported BR structures, especially for the cytosolic EF loop and the proton exit pathway. The terminal proton release complex now comprises an E194-E204 dyad as a diffuse proton buffer.

About this Structure

1BRR is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

Lipid patches in membrane protein oligomers: crystal structure of the bacteriorhodopsin-lipid complex., Essen L, Siegert R, Lehmann WD, Oesterhelt D, Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11673-8. PMID:9751724 Page seeded by OCA on Fri May 2 11:52:32 2008

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