1bs6

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[[Image:1bs6.gif|left|200px]]
[[Image:1bs6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bs6 |SIZE=350|CAPTION= <scene name='initialview01'>1bs6</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1bs6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Formylmethionine_deformylase Formylmethionine deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.31 3.5.1.31] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DEF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1bs6| PDB=1bs6 | SCENE= }}
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|RELATEDENTRY=[[1bs4|1BS4]], [[1bs5|1BS5]], [[1bs7|1BS7]], [[1bs8|1BS8]], [[1bsz|1BSZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bs6 OCA], [http://www.ebi.ac.uk/pdbsum/1bs6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bs6 RCSB]</span>
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}}
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'''PEPTIDE DEFORMYLASE AS NI2+ CONTAINING FORM IN COMPLEX WITH TRIPEPTIDE MET-ALA-SER'''
'''PEPTIDE DEFORMYLASE AS NI2+ CONTAINING FORM IN COMPLEX WITH TRIPEPTIDE MET-ALA-SER'''
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[[Category: Schultz, S.]]
[[Category: Schultz, S.]]
[[Category: Wagner, A F.V.]]
[[Category: Wagner, A F.V.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: iron metalloprotease]]
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[[Category: Iron metalloprotease]]
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[[Category: protein synthesis]]
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[[Category: Protein synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:53:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:07:10 2008''
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Revision as of 08:53, 2 May 2008

Image:1bs6.gif

Template:STRUCTURE 1bs6

PEPTIDE DEFORMYLASE AS NI2+ CONTAINING FORM IN COMPLEX WITH TRIPEPTIDE MET-ALA-SER


Overview

Eubacterial proteins are synthesized with a formyl group at the N-terminus which is hydrolytically removed from the nascent chain by the mononuclear iron enzyme peptide deformylase. Catalytic efficiency strongly depends on the identity of the bound metal. We have determined by X-ray crystallography the Fe2+, Ni2+ and Zn2+ forms of the Escherichia coli enzyme and a structure in complex with the reaction product Met-Ala-Ser. The structure of the complex, with the tripeptide bound at the active site, suggests detailed models for the mechanism of substrate recognition and catalysis. Differences of the protein structures due to the identity of the bound metal are extremely small and account only for the observation that Zn2+ binds more tightly than Fe2+ or Ni2+. The striking loss of catalytic activity of the Zn2+ form could be caused by its reluctance to change between tetrahedral and five-fold metal coordination believed to occur during catalysis. N-terminal formylation and subsequent deformylation

About this Structure

1BS6 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Iron center, substrate recognition and mechanism of peptide deformylase., Becker A, Schlichting I, Kabsch W, Groche D, Schultz S, Wagner AF, Nat Struct Biol. 1998 Dec;5(12):1053-8. PMID:9846875 Page seeded by OCA on Fri May 2 11:53:35 2008

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