1bt0
From Proteopedia
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'''STRUCTURE OF UBIQUITIN-LIKE PROTEIN, RUB1''' | '''STRUCTURE OF UBIQUITIN-LIKE PROTEIN, RUB1''' | ||
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[[Category: Delacruz, W P.]] | [[Category: Delacruz, W P.]] | ||
[[Category: Fisher, A J.]] | [[Category: Fisher, A J.]] | ||
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| - | [[Category: | + | [[Category: Rub1]] |
| - | [[Category: | + | [[Category: Ubiquitin-like protein]] |
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Revision as of 08:55, 2 May 2008
STRUCTURE OF UBIQUITIN-LIKE PROTEIN, RUB1
Overview
Several proteins with significant identity to ubiquitin have been characterized recently. In contrast to ubiquitin's main role in targeting proteins for degradation, a described function of one family of ubiquitin-related proteins, the Rub family, is to serve as a stable post-translational modification of a complex involved in the G1-to-S cell cycle transition. Rub proteins have been found in animals, plants, and fungi and consist of 76 residues with 52-63% identity to ubiquitin. In this study three different RUB proteins within the plant Arabidopsis are identified; two differ by only 1 amino acid, while the third is only 77.6% identical to the other two. Genes encoding all three are expressed in multiple organs. In addition, we report the crystal structure of higher plant RUB1 at 1.7-A resolution to help elucidate the functional differences between Rub and ubiquitin. RUB1 contains a single globular domain with a flexible COOH-terminal extension. The overall RUB1 structure is very similar to ubiquitin. The majority of the amino acid differences between RUB1 and ubiquitin map to the surface. These changes alter the electrostatic surface potential in two regions and likely confer specificity between ubiquitin and RUB1 and their ubiquitin-activating enzyme (E1) or E1-like activating enzymes.
About this Structure
1BT0 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.
Reference
The rub family of ubiquitin-like proteins. Crystal structure of Arabidopsis rub1 and expression of multiple rubs in Arabidopsis., Rao-Naik C, delaCruz W, Laplaza JM, Tan S, Callis J, Fisher AJ, J Biol Chem. 1998 Dec 25;273(52):34976-82. PMID:9857029 Page seeded by OCA on Fri May 2 11:55:14 2008
