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1etg
From Proteopedia
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(New page: 200px<br /> <applet load="1etg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1etg" /> '''REV RESPONSE ELEMENT (RRE) RNA COMPLEXED WI...)
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Revision as of 11:55, 8 November 2007
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REV RESPONSE ELEMENT (RRE) RNA COMPLEXED WITH REV PEPTIDE, NMR, 19 STRUCTURES
Overview
The solution structure of a human immunodeficiency virus type-1 (HIV-1), Rev peptide bound to stem-loop IIB of the Rev response element (RRE) RNA, was solved by nuclear magnetic resonance spectroscopy. The Rev peptide has, an alpha-helical conformation and binds in the major groove of the RNA, near a purine-rich internal loop. Several arginine side chains make, base-specific contacts, and an asparagine residue contacts a G.A base, pair. The phosphate backbone adjacent to a G.G base pair adopts an unusual, structure that allows the peptide to access a widened major groove. The, structure formed by the two purine-purine base pairs of the RRE creates a, distinctive binding pocket that the peptide can use for specific, recognition.
About this Structure
1ETG is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex., Battiste JL, Mao H, Rao NS, Tan R, Muhandiram DR, Kay LE, Frankel AD, Williamson JR, Science. 1996 Sep 13;273(5281):1547-51. PMID:8703216
Page seeded by OCA on Thu Nov 8 14:01:43 2007
