1bug

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[[Image:1bug.gif|left|200px]]
[[Image:1bug.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bug |SIZE=350|CAPTION= <scene name='initialview01'>1bug</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1bug", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CU1:Binding+Site+For+Cu+A+In+Monomer+A'>CU1</scene>, <scene name='pdbsite=CU2:Binding+Site+For+Cu+A+In+Monomer+B'>CU2</scene>, <scene name='pdbsite=CU3:Binding+Site+For+Cu+B+In+Monomer+A'>CU3</scene> and <scene name='pdbsite=CU4:Binding+Site+For+Cu+B+In+Monomer+B'>CU4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=URS:N-PHENYLTHIOUREA'>URS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_oxidase Catechol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.3.1 1.10.3.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1bug| PDB=1bug | SCENE= }}
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|RELATEDENTRY=[[1bt1|1BT1]], [[1bt2|1BT2]], [[1bt3|1BT3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bug OCA], [http://www.ebi.ac.uk/pdbsum/1bug PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bug RCSB]</span>
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}}
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'''CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)'''
'''CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)'''
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[[Category: Krebs, B.]]
[[Category: Krebs, B.]]
[[Category: Sacchettini, J C.]]
[[Category: Sacchettini, J C.]]
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[[Category: catechol oxidase]]
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[[Category: Catechol oxidase]]
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[[Category: dicopper enzyme]]
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[[Category: Dicopper enzyme]]
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[[Category: ipomoea batata]]
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[[Category: Ipomoea batata]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:58:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:08:31 2008''
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Revision as of 08:58, 2 May 2008

Image:1bug.gif

Template:STRUCTURE 1bug

CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES)-INHIBITOR COMPLEX WITH PHENYLTHIOUREA (PTU)


Overview

Catechol oxidases are ubiquitous plant enzymes containing a dinuclear copper center. In the wound-response mechanism of the plant they catalyze the oxidation of a broad range of ortho-diphenols to the corresponding o-quinones coupled with the reduction of oxygen to water. The crystal structures of the enzyme from sweet potato in the resting dicupric Cu(II)-Cu(II) state, the reduced dicuprous Cu(I)-Cu(I) form, and in complex with the inhibitor phenylthiourea were analyzed. The catalytic copper center is accommodated in a central four-helix-bundle located in a hydrophobic pocket close to the surface. Both metal binding sites are composed of three histidine ligands. His 109, ligated to the CuA site, is covalently linked to Cys 92 by an unusual thioether bond. Based on biochemical, spectroscopic and the presented structural data, a catalytical mechanism is proposed in which one of the oxygen atoms of the diphenolic substrate binds to CuB of the oxygenated enzyme.

About this Structure

1BUG is a Single protein structure of sequence from Ipomoea batatas. Full crystallographic information is available from OCA.

Reference

Crystal structure of a plant catechol oxidase containing a dicopper center., Klabunde T, Eicken C, Sacchettini JC, Krebs B, Nat Struct Biol. 1998 Dec;5(12):1084-90. PMID:9846879 Page seeded by OCA on Fri May 2 11:58:12 2008

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OCA

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