1buy

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{{Structure
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|PDB= 1buy |SIZE=350|CAPTION= <scene name='initialview01'>1buy</scene>
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The line below this paragraph, containing "STRUCTURE_1buy", creates the "Structure Box" on the page.
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{{STRUCTURE_1buy| PDB=1buy | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1buy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1buy OCA], [http://www.ebi.ac.uk/pdbsum/1buy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1buy RCSB]</span>
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'''HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE'''
'''HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE'''
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[[Category: Stevenson, J L.]]
[[Category: Stevenson, J L.]]
[[Category: Syed, R S.]]
[[Category: Syed, R S.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: growth factor]]
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[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:59:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:08:48 2008''
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Revision as of 08:59, 2 May 2008

Image:1buy.gif

Template:STRUCTURE 1buy

HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE


Overview

The solution structure of human erythropoietin (EPO) has been determined by nuclear magnetic resonance spectroscopy and the overall topology of the protein is revealed as a novel combination of features taken from both the long-chain and short-chain families of hematopoietic growth factors. Using the structure and data from mutagenesis studies we have elucidated the key physiochemical properties defining each of the two receptor binding sites on the EPO protein. A comparison of the NMR structure of the free EPO ligand to the receptor bound form, determined by X-ray crystallography, reveals conformational changes that may accompany receptor binding.

About this Structure

1BUY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

NMR structure of human erythropoietin and a comparison with its receptor bound conformation., Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS, Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:9783743 Page seeded by OCA on Fri May 2 11:59:07 2008

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OCA

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