1bxt
From Proteopedia
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'''STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES''' | '''STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES''' | ||
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[[Category: Jardetzky, T.]] | [[Category: Jardetzky, T.]] | ||
[[Category: Sundberg, E.]] | [[Category: Sundberg, E.]] | ||
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| - | [[Category: | + | [[Category: Mhc class ii interaction]] |
| - | [[Category: | + | [[Category: T cell activation]] |
| - | [[Category: | + | [[Category: Toxic shock-like syndrome]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:05:30 2008'' | |
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Revision as of 09:05, 2 May 2008
STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES
Overview
Streptococcal superantigen (SSA) is a 28,000 Mr toxin originally isolated from a pathogenic strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal enterotoxin B (SEB). SSA and SEB, however, do not compete for binding on the surfaces of cells expressing MHC class II molecules. This behavior had been ascribed to SSA and SEB binding to distinct sites on, or different subsets of, HLA-DR molecules. Here we demonstrate that SSA binds predominantly to HLA-DQ, rather than to HLA-DR molecules, and present the crystal structure of SSA at 1.85 A resolution. These data provide a structural basis for interpreting the interaction of SSA with HLA-DQ molecules as well as a foundation for understanding bacterial superantigen affinities for distinct MHC isotypes.
About this Structure
1BXT is a Single protein structure of sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.
Reference
Structural basis for HLA-DQ binding by the streptococcal superantigen SSA., Sundberg E, Jardetzky TS, Nat Struct Biol. 1999 Feb;6(2):123-9. PMID:10048922 Page seeded by OCA on Fri May 2 12:05:30 2008
