1by5

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[[Image:1by5.jpg|left|200px]]
[[Image:1by5.jpg|left|200px]]
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{{Structure
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|PDB= 1by5 |SIZE=350|CAPTION= <scene name='initialview01'>1by5</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1by5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AHO:N-ACETYL-N-HYDROXY-L-ORNITHINE'>AHO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OES:N-OCTYL-2-HYDROXYETHYL+SULFOXIDE'>OES</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1by5| PDB=1by5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1by5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1by5 OCA], [http://www.ebi.ac.uk/pdbsum/1by5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1by5 RCSB]</span>
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}}
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'''FHUA FROM E. COLI, WITH ITS LIGAND FERRICHROME'''
'''FHUA FROM E. COLI, WITH ITS LIGAND FERRICHROME'''
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[[Category: Rees, B.]]
[[Category: Rees, B.]]
[[Category: Rosenbusch, J P.]]
[[Category: Rosenbusch, J P.]]
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[[Category: ferrichrome]]
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[[Category: Ferrichrome]]
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[[Category: fhua]]
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[[Category: Fhua]]
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[[Category: iron transport]]
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[[Category: Iron transport]]
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[[Category: ligand-gated]]
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[[Category: Ligand-gated]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:06:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:10:39 2008''
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Revision as of 09:06, 2 May 2008

Image:1by5.jpg

Template:STRUCTURE 1by5

FHUA FROM E. COLI, WITH ITS LIGAND FERRICHROME


Overview

FhuA protein facilitates ligand-gated transport of ferrichrome-bound iron across Escherichia coli outer membranes. X-ray analysis at 2.7 A resolution reveals two distinct conformations in the presence and absence of ferrichrome. The monomeric protein consists of a hollow, 22-stranded, antiparallel beta barrel (residues 160-714), which is obstructed by a plug (residues 19-159). The binding site of ferrichrome, an aromatic pocket near the cell surface, undergoes minor changes upon association with the ligand. These are propagated and amplified across the plug, eventually resulting in substantially different protein conformations at the periplasmic face. Our findings reveal the mechanism of signal transmission and suggest how the energy-transducing TonB complex senses ligand binding.

About this Structure

1BY5 is a Single protein structure of sequence from Escherichia coli and Ustilago sphaerogena. Full crystallographic information is available from OCA.

Reference

Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes., Locher KP, Rees B, Koebnik R, Mitschler A, Moulinier L, Rosenbusch JP, Moras D, Cell. 1998 Dec 11;95(6):771-8. PMID:9865695 Page seeded by OCA on Fri May 2 12:06:19 2008

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