2w0v
From Proteopedia
(Difference between revisions)
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==Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 1== | ==Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 1== | ||
| - | <StructureSection load='2w0v' size='340' side='right' caption='[[2w0v]], [[Resolution|resolution]] 1.99Å' scene=''> | + | <StructureSection load='2w0v' size='340' side='right'caption='[[2w0v]], [[Resolution|resolution]] 1.99Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2w0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0V OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[2w0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W0V FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LZR:6-(CYCLOPROP-2-EN-1-YLMETHOXY)-2-[6-(CYCLOPROPYLMETHYL)-5-OXO-3,4,5,6-TETRAHYDRO-2,6-NAPHTHYRIDIN-2(1H)-YL]-7-METHOXYQUINAZOLIN-4(3H)-ONE'>LZR</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZR:6-(CYCLOPROP-2-EN-1-YLMETHOXY)-2-[6-(CYCLOPROPYLMETHYL)-5-OXO-3,4,5,6-TETRAHYDRO-2,6-NAPHTHYRIDIN-2(1H)-YL]-7-METHOXYQUINAZOLIN-4(3H)-ONE'>LZR</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v0h|2v0h]], [[2v0l|2v0l]], [[2v0j|2v0j]], [[2vd4|2vd4]], [[2w0w|2w0w]], [[2v0k|2v0k]], [[2v0i|2v0i]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v0h|2v0h]], [[2v0l|2v0l]], [[2v0j|2v0j]], [[2vd4|2vd4]], [[2w0w|2w0w]], [[2v0k|2v0k]], [[2v0i|2v0i]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-1-phosphate_N-acetyltransferase Glucosamine-1-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.157 2.3.1.157] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-1-phosphate_N-acetyltransferase Glucosamine-1-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.157 2.3.1.157] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0v OCA], [http://pdbe.org/2w0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0v RCSB], [http://www.ebi.ac.uk/pdbsum/2w0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0v ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0v ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0v ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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| + | ==See Also== | ||
| + | *[[N-acetylglucosamine-1-phosphate uridyltransferase|N-acetylglucosamine-1-phosphate uridyltransferase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Bacterium influenzae lehmann and neumann 1896]] | [[Category: Bacterium influenzae lehmann and neumann 1896]] | ||
[[Category: Glucosamine-1-phosphate N-acetyltransferase]] | [[Category: Glucosamine-1-phosphate N-acetyltransferase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Melnick, M]] | [[Category: Melnick, M]] | ||
[[Category: Mochalkin, I]] | [[Category: Mochalkin, I]] | ||
Revision as of 08:45, 25 June 2020
Crystal structure of Glmu from Haemophilus influenzae in complex with quinazoline inhibitor 1
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Categories: Bacterium influenzae lehmann and neumann 1896 | Glucosamine-1-phosphate N-acetyltransferase | Large Structures | Melnick, M | Mochalkin, I | Active site | Acyltransferase | Bacterial | Cell shape | Cell wall biogenesis/degradation | Glmu | Inhibitor | Magnesium | Metal-binding | Multifunctional enzyme | Nucleotidyltransferase | Peptidoglycan synthesis | Transferase | Uridyltransferase
