Caspase

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[[Student Projects for UMass Chemistry 423 Spring 2012-5]]<br />
[[Student Projects for UMass Chemistry 423 Spring 2012-5]]<br />
[[Caspase-3 Regulatory Mechanisms]]<br />
[[Caspase-3 Regulatory Mechanisms]]<br />
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* '''CASP-4''' binds the lipid moiety of lipopolysaccharide to induce the activation of non-canonical inflammasome<ref>PMID:29339744</ref>.<br/>
* '''CASP-6''' is involved in the activation of cascade of caspases during apoptosis. See:<br/>
* '''CASP-6''' is involved in the activation of cascade of caspases during apoptosis. See:<br/>
[[Molecular Playground/Caspase-6 (new)]]<br />
[[Molecular Playground/Caspase-6 (new)]]<br />

Revision as of 06:54, 1 July 2020

CASP-2 subunit P18 (purple, yellow) and subunit P12 (green, cyan) complex with polypeptide inhibitor (salmon, blue), aspartic aldehyde and acetyl group, 1pyo

Drag the structure with the mouse to rotate

References

  1. Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y. PMID:29339744 doi:http://dx.doi.org/10.1038/s41467-017-02682-y
  2. Schweizer A, Briand C, Grutter MG. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J Biol Chem. 2003 Oct 24;278(43):42441-7. Epub 2003 Aug 14. PMID:12920126 doi:http://dx.doi.org/10.1074/jbc.M304895200
  3. Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al.. Structure and mechanism of interleukin-1 beta converting enzyme. Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875 doi:http://dx.doi.org/10.1038/370270a0

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Michal Harel, Alexander Berchansky

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