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2w86

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Revision as of 08:20, 1 July 2020

Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form

Structural highlights

2w86 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	1uzk, 1uzj, 1uzp, 1apj, 1uzq, 1lmj
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The fibrillins and latent transforming growth factor-beta binding proteins (LTBPs) form a superfamily of structurally-related proteins consisting of calcium-binding epidermal growth factor-like (cbEGF) domains interspersed with 8-cysteine-containing transforming growth factor beta-binding protein-like (TB) and hybrid (hyb) domains. Fibrillins are the major components of the extracellular 10-12 nm diameter microfibrils, which mediate a variety of cell-matrix interactions. Here we present the crystal structure of a fibrillin-1 cbEGF9-hyb2-cbEGF10 fragment, solved to 1.8 A resolution. The hybrid domain fold is similar, but not identical, to the TB domain fold seen in previous fibrillin-1 and LTBP-1 fragments. Pairwise interactions with neighboring cbEGF domains demonstrate extensive interfaces, with the hyb2-cbEGF10 interface dependent on Ca(2+) binding. These observations provide accurate constraints for models of fibrillin organization within the 10-12 nm microfibrils and provide further molecular insights into how Ca(2+) binding influences the intermolecular interactions and biomechanical properties of fibrillin-1.

Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteins.,Jensen SA, Iqbal S, Lowe ED, Redfield C, Handford PA Structure. 2009 May 13;17(5):759-68. PMID:19446531^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Jensen SA, Iqbal S, Lowe ED, Redfield C, Handford PA. Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteins. Structure. 2009 May 13;17(5):759-68. PMID:19446531 doi:10.1016/j.str.2009.03.014

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2w86"

@@ Line 1: / Line 1: @@
 ==Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form==
-<StructureSection load='2w86' size='340' side='right' caption='[[2w86]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='2w86' size='340' side='right'caption='[[2w86]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w86]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W86 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W86 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w86]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W86 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W86 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uzk|1uzk]], [[1uzj|1uzj]], [[1uzp|1uzp]], [[1apj|1apj]], [[1uzq|1uzq]], [[1lmj|1lmj]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w86 OCA], [http://pdbe.org/2w86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w86 RCSB], [http://www.ebi.ac.uk/pdbsum/2w86 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w86 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w86 OCA], [http://pdbe.org/2w86 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w86 RCSB], [http://www.ebi.ac.uk/pdbsum/2w86 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w86 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 32: / Line 32: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Handford, P A]]
 [[Category: Iqbal, S]]

2w86

From Proteopedia

Revision as of 08:20, 1 July 2020

Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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