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2wcx

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==Crystal Structure of Hepatitis C Virus NS5B Polymerase in Complex with Thienopyrrole-Based Finger-Loop Inhibitors==
==Crystal Structure of Hepatitis C Virus NS5B Polymerase in Complex with Thienopyrrole-Based Finger-Loop Inhibitors==
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<StructureSection load='2wcx' size='340' side='right' caption='[[2wcx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='2wcx' size='340' side='right'caption='[[2wcx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wcx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WCX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wcx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcv Hcv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WCX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=VGC:6-CYCLOHEXYL-4-METHYL-5-PHENYL-4H-THIENO[3,2-B]PYRROLE-2-CARBOXYLIC+ACID'>VGC</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=VGC:6-CYCLOHEXYL-4-METHYL-5-PHENYL-4H-THIENO[3,2-B]PYRROLE-2-CARBOXYLIC+ACID'>VGC</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhu|1nhu]], [[2i1r|2i1r]], [[1jxp|1jxp]], [[2jc1|2jc1]], [[1gx6|1gx6]], [[1a1q|1a1q]], [[1c2p|1c2p]], [[1cu1|1cu1]], [[1ns3|1ns3]], [[2jc0|2jc0]], [[2ax1|2ax1]], [[1nhv|1nhv]], [[1csj|1csj]], [[2brl|2brl]], [[2brk|2brk]], [[1gx5|1gx5]], [[2ax0|2ax0]], [[2awz|2awz]], [[1quv|1quv]], [[1os5|1os5]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nhu|1nhu]], [[2i1r|2i1r]], [[1jxp|1jxp]], [[2jc1|2jc1]], [[1gx6|1gx6]], [[1a1q|1a1q]], [[1c2p|1c2p]], [[1cu1|1cu1]], [[1ns3|1ns3]], [[2jc0|2jc0]], [[2ax1|2ax1]], [[1nhv|1nhv]], [[1csj|1csj]], [[2brl|2brl]], [[2brk|2brk]], [[1gx5|1gx5]], [[2ax0|2ax0]], [[2awz|2awz]], [[1quv|1quv]], [[1os5|1os5]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcx OCA], [http://pdbe.org/2wcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wcx RCSB], [http://www.ebi.ac.uk/pdbsum/2wcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wcx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcx OCA], [http://pdbe.org/2wcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wcx RCSB], [http://www.ebi.ac.uk/pdbsum/2wcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wcx ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Hcv]]
[[Category: Hcv]]
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[[Category: Large Structures]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Marco, S Di]]
[[Category: Marco, S Di]]

Revision as of 08:34, 1 July 2020

Crystal Structure of Hepatitis C Virus NS5B Polymerase in Complex with Thienopyrrole-Based Finger-Loop Inhibitors

PDB ID 2wcx

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