Complement C4

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[[4fxk]] – hCC4-A α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains<br />
[[4fxk]] – hCC4-A α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains<br />
[[4fxg]] – hCC4-A α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains + mannan-binding lectin serine protease<br />
[[4fxg]] – hCC4-A α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains + mannan-binding lectin serine protease<br />
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+
[[6ysq]] – hCC4-B + nanobody<br />
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:09, 7 July 2020

Glycosylated human complement C4-A α chain (grey), C4 β (green) and γ chain (pink) (PDB code 4fxk)

Drag the structure with the mouse to rotate

3D structures of complement C4

Updated on 07-July-2020

5jpn, 5jtw – hCC4-A - human
1hzf – hCC4-A residues 970-1336
5jpm – hCC4-A + mannan-binding lectin serine protease
4xam – hCC4-A residues 757-1744 + hCC4-B residues 20-675
4fxk – hCC4-A α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains
4fxg – hCC4-A α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains + mannan-binding lectin serine protease
6ysq – hCC4-B + nanobody

References

  1. ↑ Nesargikar PN, Spiller B, Chavez R. The complement system: history, pathways, cascade and inhibitors. Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):103-11. doi:, 10.1556/EuJMI.2.2012.2.2. Epub 2012 Jun 13. PMID:24672678 doi:http://dx.doi.org/10.1556/EuJMI.2.2012.2.2
  2. ↑ Chen Z, Koralov SB, Kelsoe G. Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med. 2000 Nov 6;192(9):1339-52. PMID:11067882
  3. ↑ Hou S, Qi J, Liao D, Zhang Q, Fang J, Zhou Y, Liu Y, Bai L, Zhang M, Kijlstra A, Yang P. Copy number variations of complement component C4 are associated with Behcet's disease but not with ankylosing spondylitis associated with acute anterior uveitis. Arthritis Rheum. 2013 Nov;65(11):2963-70. doi: 10.1002/art.38116. PMID:23918728 doi:http://dx.doi.org/10.1002/art.38116
  4. ↑ Chowdhury SJ, Karra VK, Bharali R, Kar P. Role of complement component C4 in treatment response and disease progression in chronic hepatitis C patients. J Viral Hepat. 2015 Aug;22(8):671-4. doi: 10.1111/jvh.12383. Epub 2015 Jan 9. PMID:25573496 doi:http://dx.doi.org/10.1111/jvh.12383

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Michal Harel, Joel L. Sussman

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