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1bzy

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[[Image:1bzy.gif|left|200px]]
[[Image:1bzy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bzy |SIZE=350|CAPTION= <scene name='initialview01'>1bzy</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1bzy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IMU:PHOSPHORIC+ACID+MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL]+ESTER'>IMU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1bzy| PDB=1bzy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bzy OCA], [http://www.ebi.ac.uk/pdbsum/1bzy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bzy RCSB]</span>
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}}
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'''HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR'''
'''HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR'''
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[[Category: Shi, W.]]
[[Category: Shi, W.]]
[[Category: Tyler, P C.]]
[[Category: Tyler, P C.]]
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[[Category: hgprt]]
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[[Category: Hgprt]]
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[[Category: immucillin]]
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[[Category: Immucillin]]
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[[Category: lesch-nyhan]]
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[[Category: Lesch-nyhan]]
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[[Category: magnesium]]
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[[Category: Magnesium]]
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[[Category: neighboring group participation]]
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[[Category: Neighboring group participation]]
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[[Category: oxocarbenium ion]]
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[[Category: Oxocarbenium ion]]
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[[Category: phosphoribosyltransferase]]
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[[Category: Phosphoribosyltransferase]]
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[[Category: pyrophosphate]]
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[[Category: Pyrophosphate]]
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[[Category: transition state]]
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[[Category: Transition state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:10:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:11:48 2008''
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Revision as of 09:10, 2 May 2008

Image:1bzy.gif


PDB ID 1bzy

Drag the structure with the mouse to rotate
1bzy, resolution 2.00Å ()
Ligands: , ,
Activity: Hypoxanthine phosphoribosyltransferase, with EC number 2.4.2.8
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



HUMAN HGPRTASE WITH TRANSITION STATE INHIBITOR


Overview

The structure of human HGPRT bound to the transition-state analog immucillinGP and Mg2+-pyrophosphate has been determined to 2.0 A resolution. ImmucillinGP was designed as a stable analog with the stereoelectronic features of the transition state. Bound inhibitor at the catalytic site indicates that the oxocarbenium ion of the transition state is stabilized by neighboring-group participation from MgPPi and O5'. A short hydrogen bond forms between Asp 137 and the purine ring analog. Two Mg2+ ions sandwich the pyrophosphate and contact both hydroxyls of the ribosyl analog. The transition-state analog is shielded from bulk solvent by a catalytic loop that moves approximately 25 A to cover the active site and becomes an ordered antiparallel beta-sheet.

About this Structure

1BZY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor., Shi W, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC, Nat Struct Biol. 1999 Jun;6(6):588-93. PMID:10360366 Page seeded by OCA on Fri May 2 12:10:06 2008

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