1c1m

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[[Image:1c1m.jpg|left|200px]]
[[Image:1c1m.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1c1m |SIZE=350|CAPTION= <scene name='initialview01'>1c1m</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1c1m", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XE:XENON'>XE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1c1m| PDB=1c1m | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c1m OCA], [http://www.ebi.ac.uk/pdbsum/1c1m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c1m RCSB]</span>
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}}
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'''PORCINE ELASTASE UNDER XENON PRESSURE (8 BAR)'''
'''PORCINE ELASTASE UNDER XENON PRESSURE (8 BAR)'''
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[[Category: Prange, T.]]
[[Category: Prange, T.]]
[[Category: Schiltz, M.]]
[[Category: Schiltz, M.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: pancreas elastase]]
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[[Category: Pancreas elastase]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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[[Category: xenon]]
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[[Category: Xenon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:13:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:12:38 2008''
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Revision as of 09:13, 2 May 2008

Image:1c1m.jpg

Template:STRUCTURE 1c1m

PORCINE ELASTASE UNDER XENON PRESSURE (8 BAR)


Overview

X-ray diffraction is used to study the binding of xenon and krypton to a variety of crystallised proteins: porcine pancreatic elastase; subtilisin Carlsberg from Bacillus licheniformis; cutinase from Fusarium solani; collagenase from Hypoderma lineatum; hen egg lysozyme, the lipoamide dehydrogenase domain from the outer membrane protein P64k from Neisseria meningitidis; urate-oxidase from Aspergillus flavus, mosquitocidal delta-endotoxin CytB from Bacillus thuringiensis and the ligand-binding domain of the human nuclear retinoid-X receptor RXR-alpha. Under gas pressures ranging from 8 to 20 bar, xenon is able to bind to discrete sites in hydrophobic cavities, ligand and substrate binding pockets, and into the pore of channel-like structures. These xenon complexes can be used to map hydrophobic sites in proteins, or as heavy-atom derivatives in the isomorphous replacement method of structure determination.

About this Structure

1C1M is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Exploring hydrophobic sites in proteins with xenon or krypton., Prange T, Schiltz M, Pernot L, Colloc'h N, Longhi S, Bourguet W, Fourme R, Proteins. 1998 Jan;30(1):61-73. PMID:9443341 Page seeded by OCA on Fri May 2 12:13:34 2008

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OCA

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