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1c3d

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[[Image:1c3d.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c3d OCA], [http://www.ebi.ac.uk/pdbsum/1c3d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c3d RCSB]</span>
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'''X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2'''
'''X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2'''
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[[Category: Nagar, B.]]
[[Category: Nagar, B.]]
[[Category: Rini, J M.]]
[[Category: Rini, J M.]]
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[[Category: alpha-alpha barrel]]
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[[Category: Alpha-alpha barrel]]
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[[Category: c3]]
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[[Category: C3]]
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[[Category: c3d]]
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[[Category: C3d]]
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[[Category: complement]]
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[[Category: Complement]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:16:47 2008''
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Revision as of 09:16, 2 May 2008

Image:1c3d.gif

Template:STRUCTURE 1c3d

X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2


Overview

Activation and covalent attachment of complement component C3 to pathogens is the key step in complement-mediated host defense. Additionally, the antigen-bound C3d fragment interacts with complement receptor 2 (CR2; also known as CD21) on B cells and thereby contributes to the initiation of an acquired humoral response. The x-ray crystal structure of human C3d solved at 2.0 angstroms resolution reveals an alpha-alpha barrel with the residues responsible for thioester formation and covalent attachment at one end and an acidic pocket at the other. The structure supports a model whereby the transition of native C3 to its functionally active state involves the disruption of a complementary domain interface and provides insight into the basis for the interaction between C3d and CR2.

About this Structure

1C3D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2., Nagar B, Jones RG, Diefenbach RJ, Isenman DE, Rini JM, Science. 1998 May 22;280(5367):1277-81. PMID:9596584 Page seeded by OCA on Fri May 2 12:16:47 2008

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