5zbm

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==Structure of glycolate oxidase containing FMN from Nicotiana benthamiana==
==Structure of glycolate oxidase containing FMN from Nicotiana benthamiana==
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<StructureSection load='5zbm' size='340' side='right' caption='[[5zbm]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='5zbm' size='340' side='right'caption='[[5zbm]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zbm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZBM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicbe Nicbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZBM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZBM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zbm OCA], [http://pdbe.org/5zbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zbm RCSB], [http://www.ebi.ac.uk/pdbsum/5zbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zbm ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GOX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4100 NICBE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zbm OCA], [http://pdbe.org/5zbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zbm RCSB], [http://www.ebi.ac.uk/pdbsum/5zbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zbm ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glycolate oxidase (GOX), a flavin mononucleotide (FMN)-dependent enzyme, modulates reactive oxygen species-mediated signal transduction in green plants. It has been a target protein for crop improvement because of performing a key step in photorespiration that causes the energy losses. In human, GOX is involved in the production of oxalate, which is a key metabolite in the formation of kidney stone. Here, we report the first apo-GOX structure and its complex structure with cofactor FMN from Nicotiana benthamiana by X-ray crystallography. The binding of FMN induces a pronounced conformational change of GOX tetramer. Interestingly, a conserved pH sensor found among different species might directly regulate the binding of FMN and the enzyme activity. Combined with enzymatic experiments and biophysical analyses, we provide new insights in the molecular mechanism of regulating GOX biological activity reversibly and new methods of agricultural production and clinical application.
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Structures of glycolate oxidase from Nicotiana benthamiana reveal a conserved pH sensor affecting the binding of FMN.,Liu Y, Wu W, Chen Z Biochem Biophys Res Commun. 2018 Sep 18;503(4):3050-3056. doi:, 10.1016/j.bbrc.2018.08.092. Epub 2018 Aug 22. PMID:30143257<ref>PMID:30143257</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5zbm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
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[[Category: Nicbe]]
[[Category: Chen, Z]]
[[Category: Chen, Z]]
[[Category: Liu, Y]]
[[Category: Liu, Y]]

Revision as of 14:26, 8 July 2020

Structure of glycolate oxidase containing FMN from Nicotiana benthamiana

PDB ID 5zbm

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