6kna
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Viral Ubiquitin from Autographa californica Nucleo Polyhedrosis Virus== | ==Viral Ubiquitin from Autographa californica Nucleo Polyhedrosis Virus== | ||
| - | <StructureSection load='6kna' size='340' side='right'caption='[[6kna]]' scene=''> | + | <StructureSection load='6kna' size='340' side='right'caption='[[6kna]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6kna]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Autographa_californica_mnpv Autographa californica mnpv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KNA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kna OCA], [http://pdbe.org/6kna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kna RCSB], [http://www.ebi.ac.uk/pdbsum/6kna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kna ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ac-v-ubi, LO84_035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=307456 Autographa californica MNPV])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kna OCA], [http://pdbe.org/6kna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kna RCSB], [http://www.ebi.ac.uk/pdbsum/6kna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kna ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Baculoviridae family of viruses encode a viral Ubiquitin gene. Though the viral Ubiquitin (vUb) is homologous to the host eukaryotic Ubiquitin (Ub), its preservation in the viral genome indicates unique functions that are not compensated by the host Ub. We report the structural, biophysical, and biochemical properties of the vUb from Autographa Californica Multiple Nucleo-Polyhedrosis Virus (AcMNPV). The packing of central helix alpha1 to the beta-sheet b1-b5 is different between vUb and Ub. Consequently, its stability is lower compared to Ub. However, the surface properties, ubiquitination activity, and the interaction with Ubiquitin binding domains are similar between vUb and Ub. Interestingly, vUb forms atypical polyubiquitin chain linked by lysine at the 54th position (K54), and the deubiquitinating enzymes are ineffective against the K54-linked polyubiquitin chains. We propose that the modification of host/viral proteins with the K54-linked chains is an effective way selected by the virus to protect the vUb signal from host DUBs. | ||
| + | |||
| + | -A novel polyubiquitin chain linkage formed by viral Ubiquitin is resistant to host deubiquitinating enzymes.,Negi H, Reddy PP, Vengayil V, Patole C, Laxman S, Das R Biochem J. 2020 Jun 1. pii: 225104. doi: 10.1042/BCJ20200289. PMID:32478812<ref>PMID:32478812</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6kna" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Autographa californica mnpv]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Das R]] | + | [[Category: Das, R]] |
| - | [[Category: Negi H]] | + | [[Category: Negi, H]] |
| - | [[Category: Reddy | + | [[Category: Reddy, P P]] |
| + | [[Category: Structure from cyana 2 1]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 14:30, 8 July 2020
Viral Ubiquitin from Autographa californica Nucleo Polyhedrosis Virus
| |||||||||||
