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6v9v
From Proteopedia
(Difference between revisions)
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==Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG== | ==Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG== | ||
| - | <StructureSection load='6v9v' size='340' side='right'caption='[[6v9v]]' scene=''> | + | <StructureSection load='6v9v' size='340' side='right'caption='[[6v9v]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V9V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V9V FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6v9v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V9V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V9V FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v9v OCA], [http://pdbe.org/6v9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v9v RCSB], [http://www.ebi.ac.uk/pdbsum/6v9v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v9v ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=QT4:~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide'>QT4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPA1, ANKTM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v9v OCA], [http://pdbe.org/6v9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v9v RCSB], [http://www.ebi.ac.uk/pdbsum/6v9v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v9v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TRPA1_HUMAN TRPA1_HUMAN]] Familial episodic pain syndrome with predominantly upper body involvement. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRPA1_HUMAN TRPA1_HUMAN]] Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).[UniProtKB:Q8BLA8]<ref>PMID:20547126</ref> <ref>PMID:25389312</ref> <ref>PMID:25855297</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Zhao J]] | + | [[Category: Zhao, J]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transient receptor potential subfamily a member 1]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 14:38, 8 July 2020
Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG
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