This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6v9y
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Structure of TRPA1 bound with A-967079, PMAL-C8== | ==Structure of TRPA1 bound with A-967079, PMAL-C8== | ||
| - | <StructureSection load='6v9y' size='340' side='right'caption='[[6v9y]]' scene=''> | + | <StructureSection load='6v9y' size='340' side='right'caption='[[6v9y]], [[Resolution|resolution]] 3.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V9Y FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6v9y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V9Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V9Y FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v9y OCA], [http://pdbe.org/6v9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v9y RCSB], [http://www.ebi.ac.uk/pdbsum/6v9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v9y ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPA1, ANKTM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v9y OCA], [http://pdbe.org/6v9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v9y RCSB], [http://www.ebi.ac.uk/pdbsum/6v9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v9y ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TRPA1_HUMAN TRPA1_HUMAN]] Familial episodic pain syndrome with predominantly upper body involvement. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRPA1_HUMAN TRPA1_HUMAN]] Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).[UniProtKB:Q8BLA8]<ref>PMID:20547126</ref> <ref>PMID:25389312</ref> <ref>PMID:25855297</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Zhao J]] | + | [[Category: Zhao, J]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 14:38, 8 July 2020
Structure of TRPA1 bound with A-967079, PMAL-C8
| |||||||||||
