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6vy1

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Revision as of 14:39, 8 July 2020

Cryo-EM structure of filamentous PFD from Methanocaldococcus jannaschii

Structural highlights

6vy1 is a 14 chain structure with sequence from Metja. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	pfdA2, MJ0648 (METJA)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PFDA2_METJA] Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

Publication Abstract from PubMed

The transfer of electrons through protein complexes is central to cellular respiration. Exploiting proteins for charge transfer in a controllable fashion has the potential to revolutionize the integration of biological systems and electronic devices. Here we characterize the structure of an ultrastable protein filament and engineer the filament subunits to create electronically conductive nanowires under aqueous conditions. Cryoelectron microscopy was used to resolve the helical structure of gamma-prefoldin, a filamentous protein from a hyperthermophilic archaeon. Conjugation of tetra-heme c3-type cytochromes along the longitudinal axis of the filament created nanowires capable of long-range electron transfer. Electrochemical transport measurements indicated networks of the nanowires capable of conducting current between electrodes at the redox potential of the cytochromes. Functionalization of these highly engineerable nanowires with other molecules, such as redox enzymes, may be useful for bioelectronic applications.

Structural Determination of a Filamentous Chaperone to Fabricate Electronically Conductive Metalloprotein Nanowires.,Chen YX, Ing NL, Wang F, Xu D, Sloan NB, Lam NT, Winter DL, Egelman EH, Hochbaum AI, Clark DS, Glover DJ ACS Nano. 2020 May 7. doi: 10.1021/acsnano.9b09405. PMID:32347705^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chen YX, Ing NL, Wang F, Xu D, Sloan NB, Lam NT, Winter DL, Egelman EH, Hochbaum AI, Clark DS, Glover DJ. Structural Determination of a Filamentous Chaperone to Fabricate Electronically Conductive Metalloprotein Nanowires. ACS Nano. 2020 May 7. doi: 10.1021/acsnano.9b09405. PMID:32347705 doi:http://dx.doi.org/10.1021/acsnano.9b09405

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6vy1"

@@ Line 3: / Line 3: @@
 <StructureSection load='6vy1' size='340' side='right'caption='[[6vy1]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6vy1]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VY1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VY1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6vy1]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VY1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VY1 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vy1 OCA], [http://pdbe.org/6vy1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vy1 RCSB], [http://www.ebi.ac.uk/pdbsum/6vy1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vy1 ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pfdA2, MJ0648 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vy1 OCA], [http://pdbe.org/6vy1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vy1 RCSB], [http://www.ebi.ac.uk/pdbsum/6vy1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vy1 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
+[[Category: Metja]]
 [[Category: Chen, Y X]]
 [[Category: Clark, D S]]

6vy1

From Proteopedia

Revision as of 14:39, 8 July 2020

Cryo-EM structure of filamentous PFD from Methanocaldococcus jannaschii

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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