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2wuy

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Revision as of 14:57, 8 July 2020

the crystal structure of wild-type baculovirus polyhedra

Structural highlights

2wuy is a 1 chain structure with sequence from Acmnpv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2wux
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PYHD_NPVAC] Major component of the virus occlusion bodies, which are large proteinaceous structures (polyhedra), that protect the virus from the outside environment for extended periods until they are ingested by insect larvae.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Natural protein crystals (polyhedra) armour certain viruses, allowing them to survive for years under hostile conditions. We have determined the structure of polyhedra of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), revealing a highly symmetrical covalently cross-braced robust lattice, the subunits of which possess a flexible adaptor enabling this supra-molecular assembly to specifically entrap massive baculoviruses. Inter-subunit chemical switches modulate the controlled release of virus particles in the unusual high pH environment of the target insect's gut. Surprisingly, the polyhedrin subunits are more similar to picornavirus coat proteins than to the polyhedrin of cytoplasmic polyhedrosis virus (CPV). It is, therefore, remarkable that both AcMNPV and CPV polyhedra possess identical crystal lattices and crystal symmetry. This crystalline arrangement must be particularly well suited to the functional requirements of the polyhedra and has been either preserved or re-selected during evolution. The use of flexible adaptors to generate a powerful system for packaging irregular particles is characteristic of the AcMNPV polyhedrin and may provide a vehicle to sequester a wide range of objects such as biological nano-particles.

How baculovirus polyhedra fit square pegs into round holes to robustly package viruses.,Ji X, Sutton G, Evans G, Axford D, Owen R, Stuart DI EMBO J. 2010 Jan 20;29(2):505-14. Epub 2009 Dec 3. PMID:19959989^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ji X, Sutton G, Evans G, Axford D, Owen R, Stuart DI. How baculovirus polyhedra fit square pegs into round holes to robustly package viruses. EMBO J. 2010 Jan 20;29(2):505-14. Epub 2009 Dec 3. PMID:19959989 doi:10.1038/emboj.2009.352

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wuy"

@@ Line 1: / Line 1: @@
 ==the crystal structure of wild-type baculovirus polyhedra==
-<StructureSection load='2wuy' size='340' side='right' caption='[[2wuy]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
+<StructureSection load='2wuy' size='340' side='right'caption='[[2wuy]], [[Resolution|resolution]] 3.09&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acmnpv Acmnpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WUY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acmnpv Acmnpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WUY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WUY FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wux|2wux]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wuy OCA], [http://pdbe.org/2wuy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wuy RCSB], [http://www.ebi.ac.uk/pdbsum/2wuy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wuy ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wuy OCA], [http://pdbe.org/2wuy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wuy RCSB], [http://www.ebi.ac.uk/pdbsum/2wuy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wuy ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 33: / Line 33: @@
 </StructureSection>
 [[Category: Acmnpv]]
+[[Category: Large Structures]]
 [[Category: Axford, D]]
 [[Category: Evans, G]]

2wuy

From Proteopedia

Revision as of 14:57, 8 July 2020

the crystal structure of wild-type baculovirus polyhedra

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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