2x29

From Proteopedia

(Difference between revisions)

Revision as of 15:03, 8 July 2020

Crystal structure of human4-1BB ligand ectodomain

Structural highlights

2x29 is a 1 chain structure with sequence from Human. This structure supersedes the now removed PDB entry 2wak. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TNFL9_HUMAN] Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Binding of the 4-1BB ligand (4-1BBL) to its receptor, 4-1BB, provides the T lymphocyte with co-stimulatory signals for survival, proliferation, and differentiation. Importantly, the 4-1BB-4-1BBL pathway is a well known target for anti-cancer immunotherapy. Here we present the 2.3-A crystal structure of the extracellular domain of human 4-1BBL. The ectodomain forms a homotrimer with an extended, three-bladed propeller structure that differs from trimers formed by other members of the tumor necrosis factor (TNF) superfamily. Based on the 4-1BBL structure, we modeled its complex with 4-1BB, which was consistent with images obtained by electron microscopy, and verified the binding site by site-directed mutagenesis. This structural information will facilitate the development of immunotherapeutics targeting 4-1BB.

The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily.,Won EY, Cha K, Byun JS, Kim DU, Shin S, Ahn B, Kim YH, Rice AJ, Walz T, Kwon BS, Cho HS J Biol Chem. 2010 Mar 19;285(12):9202-10. Epub 2009 Dec 23. PMID:20032458^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Won EY, Cha K, Byun JS, Kim DU, Shin S, Ahn B, Kim YH, Rice AJ, Walz T, Kwon BS, Cho HS. The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. J Biol Chem. 2010 Mar 19;285(12):9202-10. Epub 2009 Dec 23. PMID:20032458 doi:10.1074/jbc.M109.084442

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2x29"

@@ Line 1: / Line 1: @@
 ==Crystal structure of human4-1BB ligand ectodomain==
-<StructureSection load='2x29' size='340' side='right' caption='[[2x29]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='2x29' size='340' side='right'caption='[[2x29]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2x29]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2wak 2wak]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X29 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2x29]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2wak 2wak]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X29 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X29 FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x29 OCA], [http://pdbe.org/2x29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x29 RCSB], [http://www.ebi.ac.uk/pdbsum/2x29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x29 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x29 OCA], [http://pdbe.org/2x29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x29 RCSB], [http://www.ebi.ac.uk/pdbsum/2x29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x29 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 30: / Line 30: @@
 ==See Also==
-*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
+*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
 == References ==
 <references/>
@@ Line 36: / Line 36: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Cho, H S]]
 [[Category: Won, E Y]]

2x29

From Proteopedia

Revision as of 15:03, 8 July 2020

Crystal structure of human4-1BB ligand ectodomain

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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